The new AlphaFold model demonstrates substantially improved accuracy over many previous specialized tools: far greater accuracy for protein–ligand interactions compared with state-of-the-art docking tools, much higher accuracy for protein–nucleic acid interactions compared with nucleic-acid-specific predictors and substantially higher antibody–antigen prediction accuracy.
In the past two years, significant updates were made to PubChem, including the co-occurrence data underlying the literature knowledge panel, enabling users to exploit semantic web technologies to explore entity relationships based on the co-occurrences in the scientific literature.
A comprehensive understanding of cytokine-mediated inflammatory pathways and the interplay with antioxidants is paramount for developing natural therapeutic agents targeting inflammation-related disorders and helping to improve clinical outcomes and enhance the quality of life for patients.
Tethered macrocyclic peptide antibiotics with potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii are identified and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB are reported.
It is suggested that reversible palmitoylation is a checkpoint for pore formation by both GSDMD-NT and intact GSDMD that functions as a general switch for the activation of this pore-forming family.
The narrow-window data-independent acquisition (nDIA) strategy consisting of high-resolution MS1 scans with parallel tandem MS/MS scans of ~200 Hz using 2-Th isolation windows is presented, dissolving the differences between data-dependent and -independent methods.
The proteomic mechanisms by which AgNPs exert their antimicrobial effects are investigated, with a special focus on their activity against planktonic bacteria and in biofilms and the issue of resistance to antibiotics is addressed.
These findings identify an unusual mechanism of lipid transport inhibition, reveal a druggable conformation of the Lpt transporter and provide the foundation for extending this class of antibiotics to other Gram-negative pathogens.
This review aims to provide a comprehensive overview of cisplatin toxicity, encompassing its underlying mechanisms, risk factors, and emerging therapeutic strategies, and highlights the emerging therapeutic strategies that could be applied to minimize cisplatin-induced toxicities.
The mechanisms by which complex polyphenols act as antioxidative, anti-inflammatory, and anticancer agents have been discussed and their role in food enrichment is discussed.
An assessment of the current state of microfluidic technologies for lipid-based nanoparticle and nanomedicine production is presented, with an emphasis on the capabilities of microfluidic systems for controlling nanoparticle size and size distribution.
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