The new AlphaFold model with a substantially updated diffusion-based architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues is described, showing that high-accuracy modelling across biomolecular space is possible within a single unified deep-learning framework.
The identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB are reported, and zosurabalpin, a clinical candidate derived from the MCP class, effectively treats highly drug-resistant contemporary isolates of CRAB both in vitro and in mouse models of infection.
A comprehensive understanding of cytokine-mediated inflammatory pathways and the interplay with antioxidants is paramount for developing natural therapeutic agents targeting inflammation-related disorders and helping to improve clinical outcomes and enhance the quality of life for patients.
In the past two years, significant updates were made to PubChem, including the co-occurrence data underlying the literature knowledge panel, enabling users to exploit semantic web technologies to explore entity relationships based on the co-occurrences in the scientific literature.
These findings identify an unusual mechanism of lipid transport inhibition, reveal a druggable conformation of the Lpt transporter and provide the foundation for extending this class of antibiotics to other Gram-negative pathogens.
The biogenic origin of the acyl chain is reported, the series of enzymes required for its synthesis and addition and the entire 20-step pathway in tobacco are characterized and reconstitute the entire 20-step pathway in tobacco, thereby demonstrating the production of QS-21 in a heterologous expression system.
This work demonstrates the complete biosynthesis of QS-21 and its precursors, as well as structural derivatives, in engineered yeast strains, and produces structural analogues of QS-21 using this biosynthetic platform.
The proteomic mechanisms by which AgNPs exert their antimicrobial effects are investigated, with a special focus on their activity against planktonic bacteria and in biofilms and the issue of resistance to antibiotics is addressed.
The mechanisms by which complex polyphenols act as antioxidative, anti-inflammatory, and anticancer agents have been discussed and their role in food enrichment is discussed.
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